10 papers
Effect of sub-critical fluid shear flow on granular bed strength
Dong Wang, Sophie Bodek, Nicholas T. Ouellette +2
Interactions between fluids and granular materials are prevalent on the Earth's surface. In the case of fluid flow over a sediment bed, the fluid imparts a shear stress to the gran…
Droplet Breakup Against an Isolated Obstacle
David J. Meer, Shivnag Sista, Mark D. Shattuck +2
We describe combined experiments and simulations of droplet breakup during flow-driven interactions with a circular obstacle in a quasi-two-dimensional microfluidic chamber. Due to…
Assessment of scoring functions for computational models of protein-protein interfaces
Jacob Sumner, Grace Meng, Naomi Brandt +4
A goal of computational studies of protein-protein interfaces (PPIs) is to predict the binding site between two monomers that form a heterodimer. The simplest version of this probl…
Cell Shape Emerges from Motion
Gautham Gopinath, Emmanuel Y. Mintah, Aashrith Saraswathibhatla +6
We perform cell segmentation on images from experimental studies of confluent, mobile cells in epithelial monolayers and show that these systems possess a broad, positively-skewed…
SCUDDO: An unsupervised clustering algorithm for single-cell Hi-C maps using diagonal diffusion operators
Luka Maisuradze, Corey S. O'Hern, Mark D. Shattuck
Motivation: Advances in high-throughput chromatin conformation capture have provided insight into the three-dimensional structure and organization of chromatin. While bulk Hi-C exp…
Particle-scale origin of quadrupolar non-affine displacement fields in granular solids
Evan P. Willmarth, Weiwei Jin, Dong Wang +4
In this work, we identify the local structural defects that control the non-affine displacement fields in jammed disk packings subjected to athermal, quasistatic (AQS) simple shear…