75 citations · 177 across the 11 of their papers we have counts for
Showing 2020Show all
3 papers · 1 filter
stat.ME2020★ 1 cited
Optimal Bayesian hierarchical model to accelerate the development of tissue-agnostic drugs and basket trials
Liyun Jiang, Lei Nie, Fangrong Yan +1
Tissue-agnostic trials enroll patients based on their genetic biomarkers, not tumor type, in an attempt to determine if a new drug can successfully treat disease conditions based o…
stat.ME2020★ 5 cited
Elastic Priors to Dynamically Borrow Information from Historical Data in Clinical Trials
Liyun Jiang, Lei Nie, Ying Yuan
Use of historical data and real-world evidence holds great potential to improve the efficiency of clinical trials. One major challenge is how to effectively borrow information from…
stat.ME2020★ 3 cited
Incorporating historical information to improve phase I clinical trial designs
Yanhong Zhou, J. Jack Lee, Shunguang Wang +2
Incorporating historical data or real-world evidence has a great potential to improve the efficiency of phase I clinical trials and to accelerate drug development. For model-based…