5 citations · 7 across the 5 of their papers we have counts for
5 papers
Externally Controlled Trials: A Review of Design and Borrowing Through a Causal Lens
Ke Zhu, Rima Izem, Peng Yang +8
Externally controlled trials (ECTs) are increasingly used when randomized controls are infeasible, unethical, or insufficient, including applications in rare diseases, oncology, pe…
SAM: Self-adapting Mixture Prior to Dynamically Borrow Information from Historical Data in Clinical Trials
Peng Yang, Yuansong Zhao, Lei Nie +2
Mixture priors provide an intuitive way to incorporate historical data while accounting for potential prior-data conflict by combining an informative prior with a non-informative p…
Design and Sample Size Determination for Multiple-dose Randomized Phase II Trials for Dose Optimization
Peng Yang, Daniel Li, Ruitao Lin +2
The conventional more-is-better dose selection paradigm, which targets the maximum tolerated dose (MTD), is not suitable for the development of targeted therapies and immunotherapi…
Bayesian Nonparametric Common Atoms Regression for Generating Synthetic Controls in Clinical Trials
Noirrit Kiran Chandra, Abhra Sarkar, John F. de Groot +2
The availability of electronic health records (EHR) has opened opportunities to supplement increasingly expensive and difficult to carry out randomized controlled trials (RCT) with…
BOP2-DC: Bayesian optimal phase II designs with dual-criterion decision making
Yujie Zhao, Daniel Li, Rong Liu +1
The conventional phase II trial design paradigm is to make the go/no-go decision based on the hypothesis testing framework. Statistical significance itself alone, however, may not…