85 citations · 133 across the 8 of their papers we have counts for
9 papers · 1 filter
Nonequilibrium antigen recognition during infections and vaccinations
Roberto Morán-Tovar, Michael Lässig
The immune response to an acute primary infection is a coupled process of antigen proliferation, molecular recognition by naive B cells, and their subsequent proliferation and anti…
Stochasticity of infectious outbreaks and consequences for optimal interventions
Roberto Morán-Tovar, Henning Gruell, Florian Klein +1
Global strategies to contain a pandemic, such as social distancing and protective measures, are designed to reduce the overall transmission rate between individuals. Despite such m…
Antigenic waves of virus-immune co-evolution
Jacopo Marchi, Michael Lässig, Aleksandra M. Walczak +1
The evolution of many microbes and pathogens, including circulating viruses such as seasonal influenza, is driven by immune pressure from the host population. In turn, the immune s…
Adaptive evolution of hybrid bacteria by horizontal gene transfer
Jeffrey J. Power, Fernanda Pinheiro, Simone Pompei +6
Horizontal gene transfer is an important factor in bacterial evolution that can act across species boundaries. Yet, we know little about rate and genomic targets of cross-lineage g…
Epidemiological and evolutionary analysis of the 2014 Ebola virus outbreak
Marta Łuksza, Trevor Bedford, Michael Lässig
The 2014 epidemic of the Ebola virus is governed by a genetically diverse viral population. In the early Sierra Leone outbreak, a recent study has identified new mutations that gen…
Rate and cost of adaptation in the Drosophila Genome
Stephan Schiffels, Michael Lässig, Ville Mustonen
Recent studies have consistently inferred high rates of adaptive molecular evolution between Drosophila species. At the same time, the Drosophila genome evolves under different rat…
Adaptive evolution of molecular phenotypes
Torsten Held, Armita Nourmohammad, Michael Lässig
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In…
Universality and predictability in molecular quantitative genetics
Armita Nourmohammad, Torsten Held, Michael Lässig
Molecular traits, such as gene expression levels or protein binding affinities, are increasingly accessible to quantitative measurement by modern high-throughput techniques. Such t…
Formation of regulatory modules by local sequence duplication
Armita Nourmohammad, Michael Laessig
Turnover of regulatory sequence and function is an important part of molecular evolution. But what are the modes of sequence evolution leading to rapid formation and loss of regula…