223 citations · 1.1k across the 27 of their papers we have counts for
27 papers
Predicting trajectories and mechanisms of antibiotic resistance evolution
Fernanda Pinheiro, Omar Warsi, Dan I. Andersson +1
Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet unsolved question is how resistance evolution affects cell growth at different drug levels. H…
Multi-lineage evolution in viral populations driven by host immune systems
Jacopo Marchi, Michael Lässig, Thierry Mora +1
Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary pa…
Survival of the simplest: the cost of complexity in microbial evolution
Torsten Held, Daniel Klemmer, Michael Lässig
The evolution of microbial and viral organisms often generates clonal interference, a mode of competition between genetic clades within a population. In this paper, we show that in…
Multiple-line inference of selection on quantitative traits
Nico Riedel, Bhavin S. Khatri, Michael Lässig +1
Trait differences between species may be attributable to natural selection. However, quantifying the strength of evidence for selection acting on a particular trait is a difficult…
Evolution of molecular phenotypes under stabilizing selection
Armita Nourmohammad, Stephan Schiffels, Michael Laessig
Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits…
Significance analysis and statistical mechanics: an application to clustering
Marta Łuksza, Michael Lässig, Johannes Berg
This paper addresses the statistical significance of structures in random data: Given a set of vectors and a measure of mutual similarity, how likely does a subset of these vectors…