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math.DS2021
Discrete and continuum models for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes and tumour cells
Luís Almeida, Chloe Audebert, Emma Leschiera +1
We present an individual-based model for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes (CTLs) and tumour cells. In this model, every cell is viewed as an individ…
q-bio.CB2021★ 2 cited
A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD8+ T cell immune response
Emma Leschiera, Tommaso Lorenzi, Shensi Shen +2
Intra-tumour heterogeneity (ITH) has a strong impact on the efficacy of the immune response against solid tumours. The number of sub-populations of cancer cells expressing differen…