2 citations · 2 across the 3 of their papers we have counts for
4 papers
An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids
Emma Leschiera, Gheed Al-Hity, Melanie S. Flint +4
In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol result…
A hybrid discrete-continuum modelling approach to explore the impact of T-cell infiltration on anti-tumour immune response
Luis Almeida, Chloe Audebert, Emma Leschiera +1
We present a spatial hybrid discrete-continuum modelling framework for the interaction dynamics between tumour cells and cytotoxic T cells, which play a pivotal role in the immune…
Discrete and continuum models for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes and tumour cells
Luís Almeida, Chloe Audebert, Emma Leschiera +1
We present an individual-based model for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes (CTLs) and tumour cells. In this model, every cell is viewed as an individ…
A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD8+ T cell immune response
Emma Leschiera, Tommaso Lorenzi, Shensi Shen +2
Intra-tumour heterogeneity (ITH) has a strong impact on the efficacy of the immune response against solid tumours. The number of sub-populations of cancer cells expressing differen…