3 papers
cs.SE2026
GlycoPy: A CasADi-based Python Framework for Hierarchical Modeling, Optimization, and Control of Bioprocesses
Yingjie Ma, Jing Guo, Richard D. Braatz
Efficient implementation of nonlinear model predictive control (NMPC) for bioprocesses remains challenging because large nonlinear models are difficult to organize, simulate, and e…
math.NA2025
Quasi-Steady-State Approach for Efficient Multiscale Simulation and Optimization of mAb Glycosylation in CHO Cell Culture
Yingjie Ma, Jing Guo, Andrew Maloney +1
Glycosylation is a critical quality attribute for monoclonal antibody (mAb) production, influenced by both process conditions and cellular mechanisms. Multiscale mechanistic models…
math.OC2025
Adaptive Nonlinear Model Predictive Control of Monoclonal Antibody Glycosylation in CHO Cell Culture
Yingjie Ma, Jing Guo, Alexis B. Dubs +2
N-glycosylation is a critical quality attribute of monoclonal antibodies (mAbs), the dominant class of biopharmaceuticals. Controlling glycosylation remains difficult due to intrin…