Adaptive Nonlinear Model Predictive Control of Monoclonal Antibody Glycosylation in CHO Cell Culture

Yingjie Ma, Jing Guo, Alexis B. Dubs +2

N-glycosylation is a critical quality attribute of monoclonal antibodies (mAbs), the dominant class of biopharmaceuticals. Controlling glycosylation remains difficult due to intrin…