105 citations · 120 across the 9 of their papers we have counts for
8 papers · 1 filter
Protective Effect of Trehalose Sugar on Amyloid-Membrane Interactions using BLM Electrophysiology
Yue Xu, Carina Teresa Filice, Zoya Leonenko
Alzheimer's disease (AD) is a neurodegenerative disease characterized by dementia and memory loss in the elderly population. The amyloid- peptide (A 1-42) is one of the main…
Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease
Elizabeth Drolle, Alexander Negoda, Keely Hammond +2
Amyloid beta peptides (A\b{eta}), implicated in Alzheimers disease (AD), interact with the cellular membrane and induce amyloid toxicity. The composition of cellular membranes chan…
AFM-Assisted Fabrication of Thiol SAM Pattern with Alternating Quantified Surface Potential
Brad Moores, Janet Simons, S Xu +1
Thiol self assembled monolayers (SAMs) are widely used in many nano- and bio-technology applications. We report a new approach to create and characterize a thiol SAMs micropattern…
Effect of Surfaces on Amyloid Fibril Formation
Brad Moores, Elizabeth Drolle, Simon Attwood +2
Using atomic force microscopy (AFM) we investigated the interaction of amyloid beta (Ab) (1 42) peptide with chemically modified surfaces in order to better understand the mechanis…
Cu2+ Affects Amyloid-\b{eta} (1-42) Aggregation by Increasing Peptide-Peptide Binding Forces
Francis Hane, Gary Tran, Simon Attwood +1
The link between metals, Alzheimers disease (AD) and its implicated protein, amyloid \b{eta} (A\b{eta}), is complex and highly studied. AD is believed to occur as a result of the m…
Magnetic Force Microscopy Characterization of Superparamagnetic Iron Oxide Nanoparticles (SPIONs)
Gustavo Cordova, Simon Attwood, Ravi Gaikwad +2
Superparamagnetic iron oxide nanoparticles (SPIONs), due to their controllable sizes, relatively long in vivo half-life and limited agglomeration, are ideal for biomedical applicat…
Effect of Metals on Kinetic Pathways of Amyloid-\b{eta} Aggregation
Francis Hane, Zoya Leonenko
Metal ions, including copper and zinc, have been implicated in the pathogenesis of Alzheimers disease through a variety of mechanisms including increased amyloid \b{eta} affinity a…
Drugs and Drug Delivery Systems Targeting Amyloid-\b{eta} in Alzheimers Disease
Morgan Robinson, Brenda Yasie Lee, Zoya Leonenko
Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no cure and limited treatment solutions that are unable to target any of the suspected causes. Increasing…