activity
19992005
most citedSensitivity, Specificity and the Hybridization Isotherms of DNA Chips

137 citations · 345 across the 6 of their papers we have counts for

collaborators

6 papers

cond-mat.soft2005★ 9 cited

Exact curvilinear diffusion coefficients in the repton model

Arnaud Buhot

The Rubinstein-Duke or repton model is one of the simplest lattice model of reptation for the diffusion of a polymer in a gel or a melt. Recently, a slightly modified model with ha…

q-bio.GN2005★ 96 cited

Brush Effects on DNA Chips: Thermodynamics, Kinetics and Design Guidlines

A. Halperin, A. Buhot, E. B. Zhulina

In biology experiments, oligonucleotide microarrays are contacted with a solution of long nucleic acid (NA) targets. The hybridized probes thus carry long tails. When the surface d…

q-bio.BM2004★ 46 cited

The Effects of Stacking on the Configurations and Elasticity of Single Stranded Nucleic Acids

A. Buhot, A. Halperin

Stacking interactions in single stranded nucleic acids give rise to configurations of an annealed rod-coil multiblock copolymer. Theoretical analysis identifies the resulting signa…

cond-mat.soft2003★ 137 cited

Sensitivity, Specificity and the Hybridization Isotherms of DNA Chips

A. Halperin, A. Buhot, E. B. Zhulina

Competitve hybridization, at the surface and in the bulk, lowers the sensitivity of DNA chips. Competitive surface hybridization occurs when different targets can hybridize with th…

cond-mat.soft1999★ 12 cited

On the Helix-Coil transition in grafted chains

A. Buhot, A. Halperin

The helix-coil transition is modified by grafting to a surface. This modification is studied for short peptides capable of forming -helices. Three factors are involved: (i) the…

cond-mat.soft1999★ 45 cited

The Extension of Rod-Coil Multiblock Copolymers and the Effect of the Helix-Coil Transition

A. Buhot, A. Halperin

The extension elasticity of rod-coil mutliblock copolymers is analyzed for two experimentally accessible situations. In the quenched case, when the architecture is fixed by the syn…