69 citations · 207 across the 7 of their papers we have counts for
7 papers
Numerical parameter space compression and its application to microtubule dynamic instability
Chieh-Ting Hsu, Gary J. Brouhard, Paul François
Physical models of biological systems can become difficult to interpret when they have a large number of parameters. But the models themselves actually depend on (i.e. are sensitiv…
Untangling the hairball: fitness based asymptotic reduction of biological networks
Félix Proulx-Giraldeau, Thomas J. Rademaker, Paul François
Complex mathematical models of interaction networks are routinely used for prediction in systems biology. However, it is difficult to reconcile network complexities with a formal u…
Embryonic Elongation controlled by Graded Cell Fate: A Molecular Dynamics Approach
Anna Mkrtchyan, Bertrand Bénazéraf, Olivier Pourquié +1
Regression of Hensen's node from anterior to posterior is driving the elongation and patterning of avian embryo body. Recent experiments link gradient of presomitic mesoderm cell m…
Phenotypic spandrel: absolute discrimination and ligand antagonism
Paul François, Mathieu Hemery, Kyle A. Johnson +1
We consider the general problem of sensitive and specific discrimination between biochemical species. An important instance is immune discrimination between self and not-self, wher…
The case for absolute ligand discrimination : modeling information processing and decision by immune T cells
Paul François, Grégoire Altan-Bonnet
Some cells have to take decision based on the quality of surroundings ligands, almost irrespective of their quantity, a problem we name "absolute discrimination". An example of abs…
Principles of Adaptive Sorting Revealed by In Silico Evolution
Jean-Benoît Lalanne, Paul François
Many biological networks have to filter out useful information from a vast excess of spurious interactions. We use computational evolution to predict design features of networks pr…