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stat.ME2026
PKComb-BOIN12: A Pharmacokinetically Guided Bayesian Design for Dose Optimisation in Oncology Drug-Combination Trials
Jieqi Tu, Ruitao Lin, Ayon Mukherjee
Dose optimisation of two-agent combinations in early-phase oncology trials must jointly balance toxicity, efficacy, and pharmacologically meaningful drug exposure, yet existing mod…
stat.ME2024
Online robust estimation and bootstrap inference for function-on-scalar regression
Guanghui Cheng, Wenjuan Hu, Ruitao Lin +1
We propose a novel and robust online function-on-scalar regression technique via geometric median to learn associations between functional responses and scalar covariates based on…
stat.ME2020
Mixture of Finite Mixtures Model for Basket Trial
Junxian Geng, Tianjian Zhou, Ruitao Lin +1
With the recent paradigm shift from cytotoxic drugs to new generation of target therapy and immuno-oncology therapy during oncology drug developments, patients with various cancer…