4 papers
PKComb-BOIN12: A Pharmacokinetically Guided Bayesian Design for Dose Optimisation in Oncology Drug-Combination Trials
Jieqi Tu, Ruitao Lin, Ayon Mukherjee
Dose optimisation of two-agent combinations in early-phase oncology trials must jointly balance toxicity, efficacy, and pharmacologically meaningful drug exposure, yet existing mod…
Online robust estimation and bootstrap inference for function-on-scalar regression
Guanghui Cheng, Wenjuan Hu, Ruitao Lin +1
We propose a novel and robust online function-on-scalar regression technique via geometric median to learn associations between functional responses and scalar covariates based on…
DEMO: Dose Exploration, Monitoring, and Optimization Using a Biological Mediator for Clinical Outcomes
Cheng-Han Yang, Peter F. Thall, Ruitao Lin
Phase 1-2 designs provide a methodological advance over phase 1 designs for dose finding by using both clinical response and toxicity. A phase 1-2 trial still may fail to select a…
Mixture of Finite Mixtures Model for Basket Trial
Junxian Geng, Tianjian Zhou, Ruitao Lin +1
With the recent paradigm shift from cytotoxic drugs to new generation of target therapy and immuno-oncology therapy during oncology drug developments, patients with various cancer…