2 papers
math.OC2024
Inverse extremal problem for an anti-tumor therapy model
Andrey Kovtanyuk, Christina Kuttler, Kristina Koshel +1
An optimal control problem for a model of tumor growth is studied. In a given subdomain, it is required to minimize the density of tumor cells, while the drug concentration in tiss…
q-bio.CB2023
Using systemic modeling and Bayesian calibration to investigate the role of the tumor microenvironment on chemoresistance
Sabrina Schönfeld, Laura Scarabosio, Alican Ozkan +2
Using a novel modeling approach based on the so-called environmental stress level (ESL), we develop a mathematical model to describe systematically the collective influence of oxyg…