5 papers
Synergistic interplay of morphology and metabolic activity rule response to CAR-T cells in B-cell lymphomas
Yifan Chen, Soukaina Sabir, Christina Kuttler +13
Cellular immunotherapies are one of the mainstream cancer treatments unveiling the power of the patient's immune system to fight tumors. CAR T-cell therapy, based on genetically en…
Inverse extremal problem for an anti-tumor therapy model
Andrey Kovtanyuk, Christina Kuttler, Kristina Koshel +1
An optimal control problem for a model of tumor growth is studied. In a given subdomain, it is required to minimize the density of tumor cells, while the drug concentration in tiss…
Using systemic modeling and Bayesian calibration to investigate the role of the tumor microenvironment on chemoresistance
Sabrina Schönfeld, Laura Scarabosio, Alican Ozkan +2
Using a novel modeling approach based on the so-called environmental stress level (ESL), we develop a mathematical model to describe systematically the collective influence of oxyg…
A phase-field model for non-small cell lung cancer under the effects of immunotherapy
Andreas Wagner, Pirmin Schlicke, Marvin Fritz +4
Formulating tumor models that predict growth under therapy is vital for improving patient-specific treatment plans. In this context, we present our recent work on simulating non-sm…
Environmental stress level to model tumor cell growth and survival
Sabrina Schönfeld, Alican Ozkan, Laura Scarabosio +2
Survival of living tumor cells underlies many influences such as nutrient saturation, oxygen level, drug concentrations or mechanical forces. Data-supported mathematical modeling c…