3 papers
cs.LG2026
SCALE:Scalable Conditional Atlas-Level Endpoint transport for virtual cell perturbation prediction
Shuizhou Chen, Lang Yu, Xueqin Lin +12
Virtual-cell models aim to predict how cell populations respond to perturbations, but control and treated cells are measured as unpaired populations, complicating the learning of p…
q-bio.BM2023
Accurate Prediction of Antibody Function and Structure Using Bio-Inspired Antibody Language Model
Hongtai Jing, Zhengtao Gao, Sheng Xu +7
In recent decades, antibodies have emerged as indispensable therapeutics for combating diseases, particularly viral infections. However, their development has been hindered by limi…
q-bio.BM2023
AF2-Mutation: Adversarial Sequence Mutations against AlphaFold2 on Protein Tertiary Structure Prediction
Zhongju Yuan, Tao Shen, Sheng Xu +3
Deep learning-based approaches, such as AlphaFold2 (AF2), have significantly advanced protein tertiary structure prediction, achieving results comparable to real biological experim…