4 papers
The Modified Egger Intercept Tests for Detecting Horizontal Pleiotropy in Two-Sample Summary-Data Mendelian Randomization
Yilei Ma, Youpeng Su, Xin Liu +3
The Egger intercept (EI) test is a widely used tool to detect horizontal pleiotropy in two-sample summary-data Mendelian randomization. A significant EI test suggests that either t…
Simultaneously accounting for the winner's curse and sample structure in Mendelian randomization: bivariate rerandomized inverse variance weighted estimator
Xin Liu, Youpeng Su, Chuchu Zeng +4
The recently developed rerandomized inverse variance weighted (RIVW) estimator provides a simple and efficient framework to break the winner's curse in two-sample Mendelian randomi…
Correction for Weak IV Bias and Winner's Curse in Mendelian Randomization Egger Regression: Rerandomized Egger estimator
Youpeng Su, Yilei Ma, Ping Yin +1
In two-sample Mendelian randomization (MR), Egger regression is widely used as a sensitivity analysis when directional pleiotropy is detected. However, the increasing complexity of…
A modified debiased inverse-variance weighted estimator in two-sample summary-data Mendelian randomization
Youpeng Su, Siqi Xu, Yilei Ma +4
Mendelian randomization uses genetic variants as instrumental variables to make causal inferences about the effects of modifiable risk factors on diseases from observational data.…