64 citations · 341 across the 13 of their papers we have counts for
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q-bio.BM2010★ 14 cited
Multi-scale sequence correlations increase proteome structural disorder and promiscuity
Ariel Afek, Eugene I. Shakhnovich, David B. Lukatsky
Numerous experiments demonstrate a high level of promiscuity and structural disorder in organismal proteomes. Here we ask the question what makes a protein promiscuous, i.e., prone…
q-bio.BM2010★ 12 cited
Sequence correlations shape protein promiscuity
David B. Lukatsky, Ariel Afek, Eugene I. Shakhnovich
We predict analytically that diagonal correlations of amino acid positions within protein sequences statistically enhance protein propensity for nonspecific binding. We use the ter…