64 citations · 341 across the 13 of their papers we have counts for
13 papers
Specificity-determining DNA triplet code for positioning of human pre-initiation complex
Matan Goldshtein, David B. Lukatsky
The notion that transcription factors bind DNA only through specific, consensus binding sites has been recently questioned. In a pioneering study by Pugh and Venters no specific co…
Genome-wide organization of eukaryotic pre-initiation complex is influenced by nonconsensus protein-DNA binding
Ariel Afek, David B. Lukatsky
Genome-wide binding preferences of the key components of eukaryotic pre-initiation complex (PIC) have been recently measured with high resolution in Saccharomyces cerevisiae by Rhe…
Nonspecific Protein-DNA Binding Is Widespread in the Yeast Genome
Ariel Afek, David B. Lukatsky
Recent genome-wide measurements of binding preferences of ~200 transcription regulators in the vicinity of transcription start sites in yeast, have provided a unique insight into t…
Nonspecific transcription factor-DNA binding influences nucleosome occupancy in yeast
Ariel Afek, Itamar Sela, Noa Musa-Lempel +1
Quantitative understanding of the principles regulating nucleosome occupancy on a genome-wide level is a central issue in eukaryotic genomics. Here, we address this question using…
DNA sequence correlations shape nonspecific transcription factor-DNA binding affinity
Itamar Sela, David B. Lukatsky
Transcription factors (TFs) are regulatory proteins that bind DNA in promoter regions of the genome and either promote or repress gene expression. Here we predict analytically that…
Energy fluctuations shape free energy of nonspecific biomolecular interactions
Michael Elkin, Ingemar Andre, David B. Lukatsky
Understanding design principles of biomolecular recognition is a key question of molecular biology. Yet the enormous complexity and diversity of biological molecules hamper the eff…