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physics.bio-ph2024
Identifying stable communities in Hi-C data using a multifractal null model
Lucas Hedström, Antón Carcedo Martínez, Ludvig Lizana
Chromosome capture techniques like Hi-C have expanded our understanding of mammalian genome 3D architecture and how it influences gene activity. To analyze Hi-C data sets, research…
q-bio.MN2024
A general mechanism for enhancer-insulator pairing reveals heterogeneous dynamics in long-distant 3D gene regulation
Lucas Hedström, Ralf Metzler, Ludvig Lizana
Cells regulate fates and complex body plans using spatiotemporal signaling cascades that alter gene expression. Enhancers, short DNA sequences (50-150 base pairs), help coordinate…