4 papers
Multifractal Scaling in Hi-C Maps
Seong-Gyu Yang, Lucas Hedström, Jan Smrek +1
The three-dimensional organization of the genome exhibits rich, scale-dependent structure, as revealed by both chromosome contact maps (e.g., Hi-C maps) and chromatin density measu…
Identifying stable communities in Hi-C data using a multifractal null model
Lucas Hedström, Antón Carcedo Martínez, Ludvig Lizana
Chromosome capture techniques like Hi-C have expanded our understanding of mammalian genome 3D architecture and how it influences gene activity. To analyze Hi-C data sets, research…
A general mechanism for enhancer-insulator pairing reveals heterogeneous dynamics in long-distant 3D gene regulation
Lucas Hedström, Ralf Metzler, Ludvig Lizana
Cells regulate fates and complex body plans using spatiotemporal signaling cascades that alter gene expression. Enhancers, short DNA sequences (50-150 base pairs), help coordinate…
Exploring the benefits of DNA-target search with antenna
Lucas Hedström, Ludvig Lizana
The most common gene regulation mechanism is when a protein binds to a regulatory sequence to change RNA transcription. However, these sequences are short relative to the genome le…