145 citations · 550 across the 21 of their papers we have counts for
7 papers · 1 filter
Mechanistic driven TCP and NTCP modeling for particle therapy accounting for a broad range of physical irradiation parameters and tissue environmental conditions
Marco Battestini, Jules Morand, Giulio Bordieri +3
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a sid…
A combined dose and microdosimetric modeling framework incorporating volume effects correlates with tissue sparing in proton minibeam radiotherapy
Giulio Bordieri, Marco Battestini, Gianluca Lattanzi +4
Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by…
The Biologically Effective Particle Number Ratio (BPNR): a new framework to quantify the therapeutic window in SFRT and other modalities
Niels Bassler, Giuseppe Schettino, Hugo Palmans +4
Spatially Fractionated Radiation Therapy (SFRT) produces highly heterogeneous dose distributions, for which conventional metrics such as peak, valley, or average dose can yield amb…
Integrating microdosimetric in vitro RBE models for particle therapy into TOPAS MC using the MicrOdosimetry-based modeling for RBE Assessment (MONAS) tool
Giorgio Cartechini, Marta Missiaggia, Emanuele Scifoni +2
We present MONAS (MicrOdosimetry-based modelliNg for relative biological effectiveness (RBE) ASsessment) toolkit. MONAS is a TOPAS Monte Carlo extension, that combines simulations…
An Artificial Intelligence-based model for cell killing prediction: development, validation and explainability analysis of the ANAKIN model
Francesco G. Cordoni, Marta Missiaggia, Emanuele Scifoni +1
The present work develops ANAKIN: an Artificial iNtelligence bAsed model for (radiation induced) cell KIlliNg prediction. ANAKIN is trained and tested over 513 cell survival experi…
Linking microdosimetric measurements to biological effectiveness: a review of theoretical aspects of MKM and other models
V. E. Bellinzona, F. Cordoni, M. Missiaggia +4
Different qualities of radiation are known to cause different biological effects at the same absorbed dose. Enhancements of the biological effectiveness are a direct consequence of…