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Free Growth under Tension
Chenyun Yao, Jens Elgeti
Ever since the ground breaking work of Trepat et al. in 2009, we know that cell colonies growing on a substrate can be under tensile mechanical stress. The origin of tension has so…
Mechanically-driven Stem Cell Separation in Tissues caused by Proliferating Daughter Cells
Johannes C. Krämer, Edouard Hannezo, Gerhard Gompper +1
The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be ti…
A minimal model for structure, dynamics, and tension of monolayered cell colonies
Debarati Sarkar, Gerhard Gompper, Jens Elgeti
The motion of cells in tissues is an ubiquitous phenomenon. In particular, in monolayered cell colonies in vitro, pronounced collective behavior with swirl-like motion has been obs…
The role of thickness inhomogeneities in hierarchical cortical folding
Lucas da Costa Campos, Raphael Hornung, Gerhard Gompper +2
For long it has been known that specific patterns of folding are necessary for an optimally functioning brain. For instance, lissencephaly and polymicrogyria can lead to severe men…
Mechanics of tissue competition: Interfaces stabilize coexistence
Nirmalendu Ganai, Tobias Buscher, Gerhard Gompper +1
Mechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculat…
Collective Dynamics of Self-propelled Semiflexible Filaments
Ozer Duman, Rolf E. Isele-Holder, Jens Elgeti +1
The collective behavior of active semiflexible filaments is studied with a model of tangentially driven self-propelled worm-like chains. The combination of excluded-volume interact…