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physics.comp-ph2025★ 1 cited
Bayesian MINFLUX localization microscopy
Steffen Schultze, Helmut Grubmüller
MINFLUX microscopy allows for localization of fluorophores with nanometer precision using targeted scanning with an illumination profile with a minimum. However, current scanning p…
physics.comp-ph2025
Structure determination from single-molecule X-ray scattering images using stochastic gradient ascent
Steffen Schultze, D. Russell Luke, Helmut Grubmüller
Scattering experiments using ultrashort X-ray free electron laser (XFEL) pulses have opened a new path for structure determination of a wide variety of specimens, including nano-cr…
physics.comp-ph2024
Bayesian electron density determination from sparse and noisy single-molecule X-ray scattering images
Steffen Schultze, Helmut Grubmüller
Single molecule X-ray scattering experiments using free electron lasers hold the potential to resolve both single structures and structural ensembles of biomolecules. However, mole…