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stat.ME2026
Implementing the principal stratum strategy for intercurrent events with survival outcomes: a tutorial
Xiaoxiao Zhou, Joyce Chen, Pallavi Mishra-Kalyani +5
The International Council for Harmonization (ICH) E9 (R1) addendum provides the estimand framework to formulate treatment effects in a clinical trial. One of the attributes of an e…
stat.ME2026
Two-stage Least Squares with Clustered Data under the Local Average Treatment Effect Framework
Anqi Zhao, Peng Ding, Fan Li
To estimate the causal effect of an endogenous treatment using clustered data, the canonical two-stage least squares (2sls) estimates a linear regression of the outcome on treatmen…