activity
20202024
most citedCovariate Adjustment in Randomized Clinical Trials with Missing Covariate and Outcome Data

14 citations · 47 across the 15 of their papers we have counts for

collaborators

15 papers

stat.ME2024

Assessing mediation in cross-sectional stepped wedge cluster randomized trials

Zhiqiang Cao, Fan Li

Mediation analysis has been comprehensively studied for independent data but relatively little work has been done for correlated data, especially for the increasingly adopted stepp…

stat.ME2024★ 4 cited

How should parallel cluster randomized trials with a baseline period be analyzed? A survey of estimands and common estimators

Kenneth Menglin Lee, Fan Li

The parallel cluster randomized trial with baseline (PB-CRT) is a common variant of the standard parallel cluster randomized trial (P-CRT). We define two natural estimands in the c…

stat.ME2024

What's the Weight? Estimating Controlled Outcome Differences in Complex Surveys for Health Disparities Research

Stephen Salerno, Emily K. Roberts, Belinda L. Needham +4

In this work, we are motivated by the problem of estimating racial disparities in health outcomes, specifically the average controlled difference (ACD) in telomere length between B…

stat.ME2023

Power calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint

Mary Ryan Baumann, Denise Esserman, Monica Taljaard +1

Stepped wedge cluster randomized trials (SW-CRTs) are a form of randomized trial whereby clusters are progressively transitioned from control to intervention, with the timing of tr…

stat.ME2023

Group sequential two-stage preference designs

Ruyi Liu, Fan Li, Denise Esserman +1

The two-stage preference design (TSPD) enables the inference for treatment efficacy while allowing for incorporation of patient preference to treatment. It can provide unbiased est…

stat.ME2023

Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures

Yongdong Ouyang, Monica Taljaard, Andrew B Forbes +1

Linear mixed models are commonly used in analyzing stepped-wedge cluster randomized trials (SW-CRTs). A key consideration for analyzing a SW-CRT is accounting for the potentially c…

stat.ME2023★ 11 cited

Model-assisted analysis of covariance estimators for stepped wedge cluster randomized experiments

Xinyuan Chen, Fan Li

Stepped wedge cluster randomized experiments (SW-CREs) represent a class of unidirectional crossover designs. Although SW-CREs have become popular, definitions of estimands and rob…

stat.ME2023★ 1 cited

Demystifying estimands in cluster-randomised trials

Brennan C Kahan, Bryan Blette, Michael Harhay +4

Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned to the study's objectives. Cluster randomised trials require additional at…

stat.ME2023★ 6 cited

Maximin optimal cluster randomized designs for assessing treatment effect heterogeneity

Mary M. Ryan, Denise Esserman, Fan Li

Cluster randomized trials (CRTs) are studies where treatment is randomized at the cluster level but outcomes are typically collected at the individual level. When CRTs are employed…

stat.ME2022★ 1 cited

Assessing treatment effect heterogeneity in the presence of missing effect modifier data in cluster-randomized trials

Bryan S. Blette, Scott D. Halpern, Fan Li +1

Understanding whether and how treatment effects vary across subgroups is crucial to inform clinical practice and recommendations. Accordingly, the assessment of heterogeneous treat…

stat.ME2022★ 14 cited

Covariate Adjustment in Randomized Clinical Trials with Missing Covariate and Outcome Data

Chia-Rui Chang, Yue Song, Fan Li +1

When analyzing data from randomized clinical trials, covariate adjustment can be used to account for chance imbalance in baseline covariates and to increase precision of the treatm…

stat.ME2021★ 4 cited

Addressing Extreme Propensity Scores in Estimating Counterfactual Survival Functions via the Overlap Weights

Chao Cheng, Fan Li, Laine Thomas

The inverse probability weighting approach is popular for evaluating treatment effects in observational studies, but extreme propensity scores could bias the estimator and induce e…

stat.ME2021

Clarifying Selection Bias in Cluster Randomized Trials: Estimands and Estimation

Fan Li, Zizhong Tian, Jennifer Bobb +1

In cluster randomized trials, patients are typically recruited after clusters are randomized, and the recruiters and patients may not be blinded to the assignment. This often leads…

stat.ME2021★ 1 cited

Covariate adjustment in subgroup analyses of randomized clinical trials: A propensity score approach

Siyun Yang, Fan Li, Laine E. Thomas

Background: Subgroup analyses are frequently conducted in randomized clinical trials to assess evidence of heterogeneous treatment effect across patient subpopulations. Although ra…

stat.ME2020★ 5 cited

Propensity Score Weighting for Covariate Adjustment in Randomized Clinical Trials

Shuxi Zeng, Fan Li, Rui Wang

Chance imbalance in baseline characteristics is common in randomized clinical trials. Regression adjustment such as the analysis of covariance (ANCOVA) is often used to account for…