811 citations · 7.3k across the 89 of their papers we have counts for
28 papers · 1 filter
A quantitative theory of viral-immune coevolution is within reach
Thierry Mora, Aleksandra Walczak
Pathogens drive changes in host immune systems that in turn exert pressure for pathogens to evolve. Quantifying and understanding this constant coevolutionary process has clear pra…
Evolutionary stability of antigenically escaping viruses
Victor Chardès, Andrea Mazzolini, Thierry Mora +1
Antigenic variation is the main immune escape mechanism for RNA viruses like influenza or SARS-CoV-2. While high mutation rates promote antigenic escape, they also induce large mut…
Towards a quantitative theory of tolerance
Thierry Mora, Aleksandra M. Walczak
A cornerstone of the classical view of tolerance is the elimination of self-reactive T cells during negative selection in the thymus. However, high-throughput T-cell receptor seque…
Combining mutation and recombination statistics to infer clonal families in antibody repertoires
Natanael Spisak, Gabriel Athènes, Thomas Dupic +2
B-cell repertoires are characterized by a diverse set of receptors of distinct specificities generated through two processes of somatic diversification: V(D)J recombination and som…
Inspecting the interaction between HIV and the immune system through genetic turnover
Andrea Mazzolini, Thierry Mora, Aleksandra M Walczak
Chronic infections of the human immunodeficiency virus (HIV) create a very complex co-evolutionary process, where the virus tries to escape the continuously adapting host immune sy…
Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints
Victor Chardès, Massimo Vergassola, Aleksandra M. Walczak +1
In order to target threatening pathogens, the adaptive immune system performs a continuous reorganization of its lymphocyte repertoire. Following an immune challenge, the B cell re…