811 citations · 7.3k across the 89 of their papers we have counts for
17 papers · 1 filter
Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies
Cosimo Lupo, Natanael Spisak, Aleksandra M. Walczak +1
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations o…
NoisET: Noise learning and Expansion detection of T-cell receptors
Meriem Bensouda Koraichi, Maximilian Puelma Touzel, Andrea Mazzolini +2
High-throughput sequencing of T- and B-cell receptors makes it possible to track immune repertoires across time, in different tissues, in acute and chronic diseases and in healthy…
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data
Natanael Spisak, Aleksandra M. Walczak, Thierry Mora
Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The lan…
Immune Fingerprinting through Repertoire Similarity
Thomas Dupic, Meriem Bensouda Koraichi, Anastasia Minervina +3
Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine. However, the question of how person…
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
Anastasia A. Minervina, Ekaterina A. Komech, Aleksei Titov +10
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells and facilitating the…
SOS: Online probability estimation and generation of T and B cell receptors
Giulio Isacchini, Carlos Olivares, Armita Nourmohammad +2
Recent advances in modelling VDJ recombination and subsequent selection of T and B cell receptors provide useful tools to analyze and compare immune repertoires across time, indivi…