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cs.LG2026
RosettaSearch: Multi-Objective Inference-Time Search for Protein Sequence Design
Meghana Kshirsagar, Allen Nie, Ching-An Cheng +5
We introduce RosettaSearch, an inference-time multi-objective optimization approach for backbone conditioned protein sequence design. We use large language models (LLMs) as a gener…
cs.LG2026
POLCA: Stochastic Generative Optimization with LLM
Xuanfei Ren, Allen Nie, Tengyang Xie +1
Optimizing complex systems, ranging from LLM prompts to multi-turn agents, traditionally requires labor-intensive manual iteration. We formalize this challenge as a stochastic gene…