32 citations · 81 across the 6 of their papers we have counts for
6 papers
The -activated current ensures robust and reliable signal amplification in vertebrate olfactory receptor neurons
Johannes Reisert, Jürgen Reingruber
Activation of most primary sensory neurons results in transduction currents that are carried by cations. One notable exception is the vertebrate olfactory receptor neuron (ORN), wh…
Facilitated diffusion framework for transcription factor search with conformational changes
Jérôme Cartailler, Jürgen Reingruber
Cellular responses often require the fast activation or repression of specific genes, which depends on Transcription Factors (TFs) that have to quickly find the promoters of these…
Transcription factor search for a DNA promoter in a three-states model
Juergen Reingruber, David Holcman
To ensure fast gene activation, Transcription Factors (TF) use a mechanism known as facilitated diffusion to find their DNA promoter site. Here we analyze such a process where a TF…
The Narrow Escape problem in a flat cylindrical microdomain with application to diffusion in the synaptic cleft
Juergen Reingruber, David Holcman
The mean first passage time (MFPT) for a Brownian particle to reach a small target in cellular microdomains is a key parameter for chemical activation. Although asymptotic estimati…
The Gated Narrow Escape Time for molecular signaling
Juergen Reingruber David Holcman
The mean time for a diffusing ligand to activate a target protein located on the surface of a microdomain can regulate cellular signaling. When the ligand switches between various…
Estimating the rate constant of cyclic GMP hydrolysis by activated phosphodiesterase in photoreceptors
Juergen Reingruber, david Holcman
The early steps of light response occur in the outer segment of rod and cone photoreceptor. They involve the hydrolysis of cGMP, a soluble cyclic nucleotide, that gates ionic chann…