most citedStraightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers

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stat.ME2026

PK/PD-integrated Bayesian platform design for phase II dose regimen optimization

Axel Vuorinen, Antoine Guillon, Emmanuelle Comets +2

Early-phase dose-finding methods increasingly assess toxicity and efficacy jointly, but comparisons based only on administered dose may inadequately characterize regimens differing…