36 citations · 176 across the 19 of their papers we have counts for
3 papers · 1 filter
Balancing Evidentiary Value and Sample Size of Adaptive Designs with Application to Animal Experiments
Leonhard Held, Fadoua Balabdaoui, Saverio Fontana +1
Reducing the number of experimental units is one of the three pillars of the 3R principles (Replace, Reduce, Refine) in animal research. At the same time, statistical error rates n…
Stabilizing Thompson Sampling with Null Hypothesis Bayesian Response-Adaptive Randomization
Samuel Pawel, Leonhard Held
Response-adaptive randomization (RAR) methods can be used to adapt randomization probabilities based on accumulating data, aiming to increase the probability of allocating patients…
Combined P-value Functions for Compatible Effect Estimation and Hypothesis Testing in Drug Regulation
Samuel Pawel, Małgorzata Roos, Leonhard Held
The two-trials rule in drug regulation requires statistically significant results from two pivotal trials to demonstrate efficacy. However, it is unclear how the effect estimates f…