6 citations · 15 across the 8 of their papers we have counts for
4 papers · 1 filter
Reaction-conditioned De Novo Enzyme Design with GENzyme
Chenqing Hua, Jiarui Lu, Yong Liu +7
The introduction of models like RFDiffusionAA, AlphaFold3, AlphaProteo, and Chai1 has revolutionized protein structure modeling and interaction prediction, primarily from a binding…
SurfPro: Functional Protein Design Based on Continuous Surface
Zhenqiao Song, Tinglin Huang, Lei Li +1
How can we design proteins with desired functions? We are motivated by a chemical intuition that both geometric structure and biochemical properties are critical to a protein's fun…
Protein-Nucleic Acid Complex Modeling with Frame Averaging Transformer
Tinglin Huang, Zhenqiao Song, Rex Ying +1
Nucleic acid-based drugs like aptamers have recently demonstrated great therapeutic potential. However, experimental platforms for aptamer screening are costly, and the scarcity of…
Generative Enzyme Design Guided by Functionally Important Sites and Small-Molecule Substrates
Zhenqiao Song, Yunlong Zhao, Wenxian Shi +3
Enzymes are genetically encoded biocatalysts capable of accelerating chemical reactions. How can we automatically design functional enzymes? In this paper, we propose EnzyGen, an a…