7 citations · 12 across the 9 of their papers we have counts for
6 papers · 1 filter
mRNA active transport in oocyte-early embryo: 3D agent-based modeling
Marat A. Sabirov, Ekaterina M. Myasnikova, Alexander V. Spirov
Axes of polarity (and primary morphogenetic gradients) are established in the oocyte - early embryo through active transport and localization of maternal factors. It is the oocyte…
Heuristic algorithms in Evolutionary Computations and modular organization of biological macromolecules: applications to directed evolution
Alexander Spirov, Ekaterina Myasnikova
A while ago, the ideas of evolutionary biology inspired computer scientists to develop a thriving nowadays field of evolutionary computation (EC), in general, and genetic algorithm…
Quantitative analysis of the dynamics of maternal gradients of the early Drosophila embryo
Victoria Yu. Samuta, Alexander V. Spirov
The predetermination, formation and maintenance of the primary morphogenetic gradient (bicoid gradient) of the early Drosophila embryo involves many interrelated processes. Here we…
bcd mRNA active transport: 3D agent-based modeling
Marat A. Sabirov, Victoria Yu. Samuta, Alexander V. Spirov
The article presents a 3D agent-based model to simulate the dynamics of redistribution of bicoid mRNA. The model is developed on the basis of the Skeledyne software [Odell and Foe,…
Two-exponential models of gene expression patterns for noisy experimental data
Theodore Alexandrov, Nina Golyandina, David Holloway +2
Motivation: Spatial pattern formation of the primary anterior-posterior morphogenetic gradient of the transcription factor Bicoid (Bcd) has been studied experimentally and computat…
Design of a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico
Alexander V. Spirov
New approach to design a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico is proposed. The approach is based on Genetic Algorithms, enforce…