7 citations · 12 across the 9 of their papers we have counts for
9 papers
mRNA active transport in oocyte-early embryo: 3D agent-based modeling
Marat A. Sabirov, Ekaterina M. Myasnikova, Alexander V. Spirov
Axes of polarity (and primary morphogenetic gradients) are established in the oocyte - early embryo through active transport and localization of maternal factors. It is the oocyte…
Heuristic algorithms in Evolutionary Computations and modular organization of biological macromolecules: applications to directed evolution
Alexander Spirov, Ekaterina Myasnikova
A while ago, the ideas of evolutionary biology inspired computer scientists to develop a thriving nowadays field of evolutionary computation (EC), in general, and genetic algorithm…
Quantitative analysis of the dynamics of maternal gradients of the early Drosophila embryo
Victoria Yu. Samuta, Alexander V. Spirov
The predetermination, formation and maintenance of the primary morphogenetic gradient (bicoid gradient) of the early Drosophila embryo involves many interrelated processes. Here we…
bcd mRNA active transport: 3D agent-based modeling
Marat A. Sabirov, Victoria Yu. Samuta, Alexander V. Spirov
The article presents a 3D agent-based model to simulate the dynamics of redistribution of bicoid mRNA. The model is developed on the basis of the Skeledyne software [Odell and Foe,…
Modularity in biological evolution and evolutionary computation
Anton Eremeev, Alexander Spirov
One of the main properties of biological systems is modularity, which manifests itself at all levels of their organization, starting with the level of molecular genetics, ending wi…
Modeling of gap gene regulatory networks in Drosophila with the account of the gene modular structure (in Russian)
Ekaterina Myasnikova, Alexander Spirov
Genes are frequently regulated in complex manners, necessitating modelling approaches which go beyond simple (linear) gene-to-gene interactions and address the modularity of cis-re…