3 papers
stat.AP2026
FLEX-CP-DT: A Flexible Conditional Power Framework for Interim Futility Analysis in Clinical Trials with Count Endpoints and Temporal Trends
Yanzhao Wang, Dateng Li, Ningya Wang +2
Many large-scale phase III trials with recurrent event endpoints include a pre-planned interim analysis to evaluate early futility. Conditional power (CP), which quantifies the pro…
stat.ME2025
Integrating tumor burden with survival outcome for treatment effect evaluation in oncology trials
Saurabh Bhandari, Michael J. Daniels, Chenguang Wang
In early-phase cancer clinical trials, the limited availability of data presents significant challenges in developing a framework to efficiently quantify treatment effectiveness. T…
stat.ME2025
Assessing treatment efficacy for interval-censored endpoints using multistate semi-Markov models fit to multiple data streams
Raphael Morsomme, C. Jason Liang, Allyson Mateja +4
We introduce a computationally efficient and general approach for utilizing multiple, possibly interval-censored, data streams to study complex biomedical endpoints using multistat…