4 papers · 1 filter
Validity of MMRM-based hypothesis testing under missing-not-at-random mechanisms
Kazushi Maruo, Ryota Ishii, Yusuke Yamaguchi +3
In randomized clinical trials with longitudinal continuous outcomes, missing-not-at-random (MNAR) missingness often motivates conservative alternatives to mixed models for repeated…
Outcome-blinded sample size re-estimation for externally controlled single-arm trials using baseline covariates
Keisuke Hanada, Masahiro Kojima
Externally controlled single-arm trials provide an option when limited patient populations or ethical constraints make concurrent randomized controls impractical, including in rare…
Differentially Private One-Shot Federated Inference for Linear Mixed Models via Lossless Likelihood Reconstruction
Keisuke Hanada, Toshio Shimokawa, Kazushi Maruo
One-shot federated learning enables multi-site inference with minimal communication. However, sharing summary statistics can still leak sensitive individual-level information when…
Hybrid Non-informative and Informative Prior Model-assisted Designs for Mid-trial Dose Insertion
Kana Yamada, Hisato Sunami, Kentaro Takeda +2
In oncology phase I trials, model-assisted designs have been increasingly adopted because they enable adaptive yet operationally simple dose adjustment based on accumulating safety…