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q-bio.PE2024
A statistical framework for detecting therapy-induced resistance from drug screens
Chenyu Wu, Einar Bjarki Gunnarsson, Jasmine Foo +1
Resistance to therapy remains a significant challenge in cancer treatment, often due to the presence of a stem-like cell population that drives tumor recurrence post-treatment. Mor…
q-bio.PE2015
Spatial measures of genetic heterogeneity during carcinogenesis
K. Storey, M. D. Ryser, K. Leder +1
In this work we explore the temporal dynamics of spatial heterogeneity during the process of tumorigenesis from healthy tissue. We utilize a spatial stochastic process model of mut…