AQP4 Regulates Gap-Dominated Glymphatic Clearance through Dynamic Gliovascular Coupling

Tanran Zhang, Huaxiong Huang, Robert Eisenberg +1

Aquaporin-4 (AQP4) is enriched at perivascular astrocytic endfeet, and impaired AQP4 function or localization is associated with reduced glymphatic transport. However, mechanical m…