5 papers
AQP4 Regulates Gap-Dominated Glymphatic Clearance through Dynamic Gliovascular Coupling
Tanran Zhang, Huaxiong Huang, Robert Eisenberg +1
Aquaporin-4 (AQP4) is enriched at perivascular astrocytic endfeet, and impaired AQP4 function or localization is associated with reduced glymphatic transport. However, mechanical m…
A novel multiscale modelling for the hemodynamics in retinal microcirculation with an analytic solution for the capillary-tissue coupled system
Chang Lin, Zilong Song, Robert Eisenberg +2
Mathematical modelling of the microcirculatory hemodynamics in the retina is an essential tool for understanding various diseases of the retina, yet remains challenging due to the…
Glymphatic Clearance in the Optic Nerve: A Multidomain Electro-osmostic Model
Shanfeng Xiao, Huaxiong Huang, Robert Eisenberg +2
Effective metabolic waste clearance and maintaining ionic homeostasis are essential for the health and normal function of the central nervous system. To understand its mechanism an…
Multidomain Model for Optic Nerve Potassium Clearance: Roles of Glial Cells and Perivascular Spaces
Shanfeng Xiao, Huaxiong Huang, Robert Eisenberg +2
The accumulation of potassium in the extracellular space surrounding nerve cells is a fundamental aspect of biophysics that has garnered significant attention in recent research. T…
A multi-domain model for microcirculation in optic nerve: blood flow and oxygen transport
Zilong Song, Shixin Xu, Robert Eisenberg +1
Microcirculation of blood and oxygen transport play important roles in biological function of optic nerve and are directly affected by damages or pathologies. This work develops a…