10 papers
Spatial-Molecular Information Analysis Based on Histopathological Geometry: KL-Divergence Decomposition of Cell Distribution and Location-Dependent Expression States in PD-1 Immunohistochemistry
Tatsuaki Tsuruyama
Spatial biology enables molecular expression to be analyzed together with the location of cells in tissue. However, it is often difficult to distinguish whether cells preferentiall…
A Comparison of Whole Slide Image Analysis and Diagnostic Field Selection in Pathology AI under Finite Resources
Tatsuaki Tsuruyama
An important question in pathology AI is how to allocate limited analytical resources between broad coverage of a whole slide image (WSI) and detailed analysis of selected regions.…
Mutual-Information-Dependent Nonlinear Threshold Response Model Linked to the Free Energy Principle
Tatsuaki Tsuruyama
Biological systems not only infer states of the external world from sensory input but also vary the expression of their responses according to the information they have acquired. H…
Fluctuation Theorems from a Continuous-Time Markov Model of Information-Thermodynamic Capacity in Biochemical Signal Cascades
Tatsuaki Tsuruyama
Biochemical signaling cascades transmit intracellular information while dissipating energy under nonequilibrium conditions. We model a cascade as a code string and apply informatio…
Thermodynamics Reconstructed from Information Theory:An Axiomatic Framework via Information-Volume Constraints and Path-Space KL Divergence
Tatsuaki Tsuruyama
We develop an axiomatic reconstruction of thermodynamics based entirely on two primitive components: a description of what aspects of a system are observed and a reference measure…
Slowdown and saturation of internal time according to the statistics of information input: a minimal model of response systems
Tatsuaki Tsuruyama
We consider a response system that updates its internal state in accordance with information input arriving from outside. In this paper, we define as internal time the ``number of…