3 papers
physics.med-ph2026
Mechanistic driven TCP and NTCP modeling for particle therapy accounting for a broad range of physical irradiation parameters and tissue environmental conditions
Marco Battestini, Jules Morand, Giulio Bordieri +3
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a sid…
physics.med-ph2026
A combined dose and microdosimetric modeling framework incorporating volume effects correlates with tissue sparing in proton minibeam radiotherapy
Giulio Bordieri, Marco Battestini, Gianluca Lattanzi +4
Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by…
physics.bio-ph2024
A multiscale radiation biophysical stochastic model describing the cell survival response at ultra-high dose rate
Marco Battestini, Marta Missiaggia, Sara Bolzoni +2
Ultra-high dose-rate (UHDR) radiotherapy, characterized by an extremely high radiation delivery rate, represents one of the most recent and promising frontier in radiotherapy. UHDR…