3 papers
stat.ME2026
Capturing Cumulative Disease Burden in Chronic Kidney Disease Outcome Trials: Area Under the Curve and Restricted Mean Time in Favor of Treatment Beyond Conventional Time-to-First Analysis
Jiren Sun, Tuo Wang, Yu Du
Chronic kidney disease (CKD) affects millions worldwide and progresses irreversibly through stages culminating in end-stage renal disease (ESRD) and death. Outcome trials in CKD tr…
stat.ME2025
Estimand framework development for eGFR slope estimation and comparative analyses across various estimation methods
Tuo Wang, Yu Du
Chronic kidney disease (CKD) is a global health challenge characterized by progressive kidney function decline, often culminating in end-stage kidney disease (ESKD) and increased m…
stat.ME2025
Interpretational challenges of the Win Ratio in analyzing Hierarchical Composite Endpoints in Chronic Kidney Disease
Henrik F. Thomsen, Samvel B. Gasparyan, Julie F. Furberg +7
Win statistics based methods have gained traction as a method for analyzing Hierarchical Composite Endpoints (HCEs) in randomized clinical trials, particularly in cardiovascular an…