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q-bio.QM2026
Rank-and-Reason: Multi-Agent Collaboration Accelerates Zero-Shot Protein Mutation Prediction
Yang Tan, Yuanxi Yu, Can Wu +7
Zero-shot mutation prediction is vital for low-resource protein engineering, yet existing protein language models (PLMs) often yield statistically confident results that ignore fun…
q-bio.QM2025
Sequence-Only Prediction of Binding Affinity Changes: A Robust and Interpretable Model for Antibody Engineering
Chen Liu, Mingchen Li, Yang Tan +3
A pivotal area of research in antibody engineering is to find effective modifications that enhance antibody-antigen binding affinity. Traditional wet-lab experiments assess mutants…