4 papers
When Genomic Masking Priors Fail to Transfer: Strong Variant Prediction, Weak Functional Generation
Susu Hu, Preetam Gattogi, Jens Lehmann +3
Bidirectional discrete diffusion model appears naturally suited to genomic modeling because it can reconstruct missing sequence from both flanks. We developed GenDA (Genomic Densit…
HistoPrism: Unlocking Functional Pathway Analysis from Pan-Cancer Histology via Gene Expression Prediction
Susu Hu, Qinghe Zeng, Nithya Bhasker +2
Predicting spatial gene expression from H&E histology offers a scalable and clinically accessible alternative to sequencing, but realizing clinical impact requires models that gene…
Adaptive-CaRe: Adaptive Causal Regularization for Robust Outcome Prediction
Nithya Bhasker, Fiona R. Kolbinger, Susu Hu +2
Accurate prediction of outcomes is crucial for clinical decision-making and personalized patient care. Supervised machine learning algorithms, which are commonly used for outcome p…
MoLF: Mixture-of-Latent-Flow for Pan-Cancer Spatial Gene Expression Prediction from Histology
Susu Hu, Stefanie Speidel
Inferring spatial transcriptomics (ST) from histology enables scalable histogenomic profiling, yet current methods are largely restricted to single-tissue models. This fragmentatio…