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cs.LG2026
Spatial Transcriptomics-Guided Alignment Enhances Molecular Profiling in Pathology Foundation Model
Fengtao Zhou, Yingxue Xu, Zhengyu Zhang +20
Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times. While…
q-bio.QM2026
DXA-Derived Skeletal Phenotypes and Hip Fracture Risk: A Backdoor-Adjusted Causal Analysis
Zixin Shi, Chen Zhao, Meiling Zhou +8
Purpose: To compare dual-energy X-ray absorptiometry (DXA)-derived hip skeletal phenotypes in relation to hip fracture risk using prespecified confounder adjustment and to assess w…
q-bio.GN2026
GenoBERT: A Language Model for Accurate Genotype Imputation
Lei Huang, Chuan Qiu, Kuan-Jui Su +13
Genotype imputation enables dense variant coverage for genome-wide association and risk-prediction studies, yet conventional reference-panel methods remain limited by ancestry bias…