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physics.bio-ph2026

Emergence of criticality in models of real neurons

David P. Carcamo, Christopher W. Lynn

Critical systems sit near boundaries between qualitatively distinct behaviors. When inferring models of neural activity, this proximity to criticality is thought to require the pre…

physics.bio-ph2025

Quantifying the compressibility of the human brain

Nicholas J. Weaver, Joshua I. Faskowitz, Richard F. Betzel +1

In the human brain, the allowed patterns of activity are constrained by the correlations between brain regions. Yet it remains unclear which correlations -- and how many -- are nee…

physics.bio-ph2025

Neural subspaces, minimax entropy, and mean-field theory for networks of neurons

Luca Di Carlo, Francesca Mignacco, Christopher W. Lynn +1

Recent advances in experimental techniques enable the simultaneous recording of activity from thousands of neurons in the brain, presenting both an opportunity and a challenge: to…

physics.bio-ph2025

Extended mean-field theories for networks of real neurons

Luca Di Carlo, Francesca Mignacco, Christopher W. Lynn +1

If the behavior of a system with many degrees of freedom can be captured by a small number of collective variables, then plausibly there is an underlying mean-field theory. We show…

physics.bio-ph2025

Direct dependencies between neurons explain activity

Christopher W. Lynn

Our understanding of neural computation is founded on the assumption that neurons fire in response to a linear summation of inputs. Yet experiments demonstrate that some neurons ar…

physics.bio-ph2024

Statistical physics of large-scale neural activity with loops

David P. Carcamo, Christopher W. Lynn

As experiments advance to record from tens of thousands of neurons, statistical physics provides a framework for understanding how collective activity emerges from networks of fine…