10 papers
Designing DNA nanostar hydrogels with programmable degradation and antibody release
Giorgia Palombo, Christine A. Merrick, Jennifer Harnett +3
DNA nanostar (DNAns) hydrogels are promising materials for \textit{in vivo} applications, including tissue regeneration and drug and antibody delivery. However, a systematic and qu…
NANOG assembles into self-limiting aging micelles that drive a sol-gel transition and modulate DNA dynamics
Amandine Hong-Minh, Yair Augusto Gutierrez Fosado, Abbie Guild +4
Proteins and nucleic acids form non-Newtonian liquids with complex rheological properties that contribute to their function in vivo. Here we investigate the rheology of the transcr…
Rheology and Programmable Gelation of DNA Origami Polymer Tadpoles
Jennifer Harnett, Saminathan Ramakrishnan, Alice L. B. Pyne +2
DNA origami is a powerful method to achieve nanoscale folded structures. Despite rapid improvements in folding and purification methods, DNA origami objects are still often produce…
Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA
Filippo Conforto, Antonio Valdes, Willem Vanderlinden +1
Structural-Maintenance-of-Chromosome (SMC) complexes such as condensins organise the folding of chromosomes. However, their role in modulating the entanglement of DNA and chromatin…
Binding Kinetics Oppositely Regulates type II Topoisomerase Relaxation and Decatenation Activities
Cleis Battaglia, Filippo Conforto, Yair Augusto Gutierrez Fosado +4
Type II Topoisomerases (topo II) are critical to simplify genome topology during transcription and replication. They identify topological problems and resolve them by passing a dou…
Modulation of DNA rheology by a transcription factor that forms aging microgels
Amandine Hong-Minh, Yair Augusto Gutiérrez Fosado, Abbie Guild +4
Proteins and nucleic acids form non-Newtonian liquids with complex rheological properties that contribute to their function in vivo. Here we investigate the rheology of the transcr…