2.2k citations · 4k across the 13 of their papers we have counts for
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Optimal experimental design in an EGFR signaling and down-regulation model
Fergal P. Casey, Dan Baird, Qiyu Feng +6
We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The mo…
Variational method for estimating the rate of convergence of Markov Chain Monte Carlo algorithms
Fergal P. Casey, Joshua J. Waterfall, Ryan N. Gutenkunst +2
We demonstrate the use of a variational method to determine a quantitative lower bound on the rate of convergence of Markov Chain Monte Carlo (MCMC) algorithms as a function of the…
The sloppy model universality class and the Vandermonde matrix
Joshua J. Waterfall, Fergal P. Casey, Ryan N. Gutenkunst +5
In a variety of contexts, physicists study complex, nonlinear models with many unknown or tunable parameters to explain experimental data. We explain why such systems so often are…